Detection of HuangLongBing

Citrus huanglongbing (HLB, ex greening) is one of the most serious and destructive citrus diseases in the world, responsible for increasing economic losses worldwide in the recent years. The aim of this project is the realization of electrochemical biosensors based on ZnO nanostructures, for the early detection of specific metabolites produced by citrus plants infected with HLB. In particular, we are interested in achieving high speed of detection associated with the ability to perform first screening on the field. Our research focusses on:

• Stable and homogenous immobilization of ZnO nanostructures on metal electrodes:

Stable immobilization and homogenous distribution of ZnO nanostructures on solid substrates can play a fundamental role in optimizing nanostructured devices based on this material.


AFM phase image of ZnO nanoparticles deposited on organophosphonate SAMs

The stability of ZnO nanoparticles (NPs) deposited into different self-assembled monolayers on gold electrodes shows a dramatic dependence on the SAMs terminal group. Mercapto-alkyllphosphonic acids can form uniform and conformal monolayers on gold through the thiol group and the phosphonic acid at the distal ends of the resulting monolayer can be used as anchoring group to covalently bind the ZnO nanoparticles. The application of this chemistry can be used as a powerful tool for the fabrication of designed architectures of ZnO nanostructures on metal electrodes. The improved stability of ZnO nanostructures on these substrates can be investigated  by X-ray photoelectron spectroscopy (XPS), and surface morphological structure analysis (atomic force microscopy and scanning tunneling microscopy).

• Biofunctionalization of ZnO nanostructures:

Nanostructured zinc oxide (ZnO) not only possesses a high surface area and good biocompatibility, but it also shows biomimetic and specific electron transport features, making it an interesting material for potential applications in biosensing. One of the primary drivers to enhance and tailor the function and performance of ZnO in sensing is the capability to immobilize tailored molecular and biomolecular layers on ZnO surfaces. Interfaces that enable such attachment can permit conformational control of surface-bound receptors with high target molecule binding efficiencies. 


Rossana E. Madrid, Lab. De Medios e Interfases (LAMEIN), Dpto. Bioingeniería, Universidad Nacional de Tucumán, and INSIBIO-CONICET, Argentina

Open Positions

if you would like to join us as an internship or master student on this project, please contact Anna Cattani-Scholz.




TUM Technische Universität München TUM Technische Universität München Physik Department Elektrotechnik und Informationstechnik TUM Technische Universität München

Events & News

17 Jan 2018

ERC Consolidator Grant for Gregor Koblmüller   more

16 Jan 2018

Light-steering of spin-polarized currents in topological insulators   more

10 Aug 2017

Best Poster Awards for Ganpath Veerabathran and Alexander Andrejew at iNOW 2017   more

27 Jun 2017

Best Poster Award at Nanowire Week for Jochen Bissinger   more

15 Mar 2017

Dr. Kai Müller admitted to the “Junges Kolleg” of the Bavarian Academy of Sciences   more


March 12, 2018

Two-dimensional coherent spectroscopy of a semiconductor microcavity   more

March 05, 2018

Diamond-organic photovoltaics   more